Post by shahadat560 on Jan 18, 2024 5:05:35 GMT -5
Researchers from the Microbiology and Infectious Diseases Service of the Gregorio Marañón Hospital in Madrid have begun an investigation to determine if there are factors that favor or protect patients with HIV against the incidence of symptomatic or asymptomatic coronavirus infection.
The Marañón researchers are looking for an explanation for the low proportion of people with HIV among those hospitalized for Covid-19 , which in Spain is approximately 0.7 percent , that is, only seven out of every thousand patients who have been admitted have infection with HIV as an underlying disease.
In a statement, the hospital points out that of the large series published to date of patients hospitalized with coronavirus, the presence of diseases such as hypertension , diabetes and chronic heart disease is common , but HIV infection is very rare .
This allows them to support their hypothesis that Country Email List some antiretroviral drugs could have some protective effect against coronavirus infection.
The project will be carried out in the Cohort of the AIDS Research Network (CoRIS), made up of 15,000 patients with HIV infection followed prospectively since 2004 in more than 40 hospital centers and with samples archived periodically in the Gregorio BioBank. Cashew.
The primary objective is to discover the frequency and epidemiological and clinical characteristics of patients with Covid-19 in this group, the prognostic factors for requiring intensive care, use of mechanical ventilation, duration of admission and mortality throughout 2020.
In addition, the researchers will try to study the seroprevalence of antibodies against the coronavirus by determining IgG antibodies using enzyme-linked immunosorbent assay (ELISA), in samples archived in BioBanco HIV throughout the second half of 2020 and first half of 2021. .
For this study, just over 1,500 plasma samples will be randomly selected .
The principal investigator of the project, Dr. Juan Berenguer , indicates in statements sent to the media that the availability of this cohort will allow reliable information to be obtained on many aspects related to the coronavirus in patients with HIV.
The Marañón researchers are looking for an explanation for the low proportion of people with HIV among those hospitalized for Covid-19 , which in Spain is approximately 0.7 percent , that is, only seven out of every thousand patients who have been admitted have infection with HIV as an underlying disease.
In a statement, the hospital points out that of the large series published to date of patients hospitalized with coronavirus, the presence of diseases such as hypertension , diabetes and chronic heart disease is common , but HIV infection is very rare .
This allows them to support their hypothesis that Country Email List some antiretroviral drugs could have some protective effect against coronavirus infection.
The project will be carried out in the Cohort of the AIDS Research Network (CoRIS), made up of 15,000 patients with HIV infection followed prospectively since 2004 in more than 40 hospital centers and with samples archived periodically in the Gregorio BioBank. Cashew.
The primary objective is to discover the frequency and epidemiological and clinical characteristics of patients with Covid-19 in this group, the prognostic factors for requiring intensive care, use of mechanical ventilation, duration of admission and mortality throughout 2020.
In addition, the researchers will try to study the seroprevalence of antibodies against the coronavirus by determining IgG antibodies using enzyme-linked immunosorbent assay (ELISA), in samples archived in BioBanco HIV throughout the second half of 2020 and first half of 2021. .
For this study, just over 1,500 plasma samples will be randomly selected .
The principal investigator of the project, Dr. Juan Berenguer , indicates in statements sent to the media that the availability of this cohort will allow reliable information to be obtained on many aspects related to the coronavirus in patients with HIV.